RBL2 Polyclonal Antibody | E-AB-19324

RBL2 Polyclonal Antibody | E-AB-19324 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 130 kDa retinoblastoma associated protein, 130 kDa retinoblastoma-associated protein, IB4, p130, PPAR-alpha-interacting complex protein 128, PRB2, Rb2, Rbl2, RBL2, RBR 2, RBR-2, RBR2, Retinoblastoma like 2, Retinoblastoma-like protein 2, Retinoblastoma-related protein 2, RIC128

Application: IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Concentration: 0.8 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human RBL2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A