RCN3 Antibody (Center) [AMM07556G]

RCN3 Antibody (Center) [AMM07556G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This RCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human RCN3.

Cellular Localisation: Endoplasmic reticulum lumen

Molecular Weight: 37493

Clone: Polyclonal

Gene Name: RCN3 (HGNC:21145)

Gene ID: 57333

Function: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891) . Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant- associated protein D/SP-D and the lipid transporter ABCA3 (By similarity) . By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity) . Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891) . This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634) .

Summary: Tissue Location: Widely expressed..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: FC, WB

Dilution: WB--1:2000 FC--1:10~50

Synonyms: Reticulocalbin-3, EF-hand calcium-binding protein RLP49, RCN3