RCVRN Antibody (C-term) [APR13105G]

RCVRN Antibody (C-term) [APR13105G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M, Rat

Specificity: This RCVRN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 137-171 amino acids from the C-terminal region of human RCVRN.

Cellular Localisation: Photoreceptor inner segment {ECO:0000250|UniProtKB:P34057}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P34057}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity) . Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity) {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}

Molecular Weight: 23130

Clone: Polyclonal

Gene Name: RCVRN

Gene ID: 5957

Function: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity) . Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity) . In response to high Ca (2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity) . Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity) . Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity) .

Summary: Tissue Location: Retina and pineal gland.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Recoverin, Cancer-associated retinopathy protein, Protein CAR, RCVRN, RCV1