Recombinant Human MIP-1 alpha (CCL3) Protein [E. coli] | 100-073S/100-073

Recombinant Human MIP-1 alpha (CCL3) Protein [E. coli] | 100-073S/100-073 | Gentaur UK, US & Europe Distribution

Species: Human

Host / biotech: E. coli

Comment: N/A

Label: N/A

Clone / Antibody feature: N/A

Subcategory: Cytokines & Growth Factors

Category: Recombinant Protein

Synonyms: CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha

Isotype: N/A

Application: N/A

Detection Range: Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.

Species Reactivity/Cross reactivity: Cow, Frog, Hamster, Monkey, Mouse, Rat, Human, Leech

Antigen: N/A

Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant human MIP-1 alpha is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Purity Confirmation: > 98% by SDS-PAGE & HPLC analysis

Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)

Formulation: lyophilized

Storage Handling Stability: N/A

Reconstituation: N/A

Molecular Weight: 7.8 kDa

Lenght (aa): 69

Protein Sequence: ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA

NCBI Gene ID: 6348