Recombinant Human Soluble Interleukin-6 (IL-6) Receptor | 4598

The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component specific to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low affinity binding sites for IL-6 is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6 kDa protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).

4598 | Recombinant Human Soluble Interleukin-6 IL-6 Receptor DataSheet

Biomolecule/Target: Interleukin-6 (IL-6) Receptor

Synonyms: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Alternates names: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Taglines: >98% Pure, Active, Human Recombinant Soluble Interleukin-6 (IL-6) Receptor

NCBI Gene ID #: 347

NCBI Gene Symbol: Apo-D

Gene Source: Human

Accession #: P05089

Recombinant: Yes

Source: CHO cells

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.

Biological activity:

Results: The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 37.6 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 1X PBS, pH 7.2

Reconstitution Instructions: Reconstitute in dHO to a working volume of 0.5 mg/ml and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A