Recombinant Human TIMD3 Protein (C-His Tag) | PH0093M1

Recombinant Human TIMD3 Protein (C-His Tag) | PH0093M1 | Gentaur UK, US & Europe Distribution

Short Description: Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene. HAVCR2 was first described in 2002 as a cell surface molecule expressed on IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. Later, the expression was detected in Th17 cells, regulatory T-cells, and innate immune cells (dendritic cells, NK cells, monocytes) .HAVCR2 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8+ T-cell exhaustion. HAVCR2 has also been shown as a CD4+ Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

Product Type: Cytokine

Form: lyophilized

Purity: Greater than 95% by SDS-PAGE

Storage: -70°C

Buffer: 0.2 μm filtered PBS, pH7.4