Recombinant Human TRAIL R-1/DR4, soluble Protein [E. coli] | S01-035/S01-035S

Recombinant Human TRAIL R-1/DR4, soluble Protein [E. coli] | S01-035/S01-035S | Gentaur UK, US & Europe Distribution

Species: Human

Host / biotech: E. coli

Comment: N/A

Label: N/A

Clone / Antibody feature: N/A

Subcategory: Soluble Receptors

Category: Recombinant Protein

Synonyms: TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1

Isotype: N/A

Application: N/A

Detection Range: Measured by its ability to inhibit apoptosis in LN-18 cells.  The expected ED50 for this effect is 0.4 -0.5 µg/ml.

Species Reactivity/Cross reactivity: Human

Antigen: N/A

Description: TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.

Purity Confirmation: > 98% by SDS-PAGE & HPLC analyses

Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)

Formulation: lyophilized

Storage Handling Stability: N/A

Reconstituation: N/A

Molecular Weight: 22.7 kDa

Lenght (aa): 215

Protein Sequence: MSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSTGCPR GMVKVKDCTP WSDIECVHKE SGNGHN

NCBI Gene ID: 8797