Recombinant Human TWEAK receptor, soluble Protein [E. coli] | S01-037S/S01-037

Recombinant Human TWEAK receptor, soluble Protein [E. coli] | S01-037S/S01-037 | Gentaur UK, US & Europe Distribution

Species: Human

Host / biotech: E. coli

Comment: N/A

Label: N/A

Clone / Antibody feature: N/A

Subcategory: Soluble Receptors

Category: Recombinant Protein

Synonyms: TNFRSF12A; FN14; CD266; TWEAKR

Isotype: N/A

Application: N/A

Detection Range: Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml.

Species Reactivity/Cross reactivity: Human

Antigen: N/A

Description: TWEAK-R belongs to the TNF family of transmembrane proteins and contains a cytoplasmic „death domain“, which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK-R can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAK-R is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAK-R protein.

Purity Confirmation: > 98% by SDS-PAGE & HPLC analyses

Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)

Formulation: lyophilized

Storage Handling Stability: N/A

Reconstituation: N/A

Molecular Weight: 5.6 kDa

Lenght (aa): 53

Protein Sequence: EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

NCBI Gene ID: 51330