Recoverin Antibody (C-term) [APR13108G]

Recoverin Antibody (C-term) [APR13108G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This Recoverin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-200 amino acids from the C-terminal region of human Recoverin.

Cellular Localisation: Photoreceptor inner segment {ECO:0000250|UniProtKB:P34057}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P34057}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity) . Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity) {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}

Molecular Weight: 23130

Clone: Polyclonal

Gene Name: RCVRN

Gene ID: 5957

Function: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity) . Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity) . In response to high Ca (2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity) . Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity) . Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity) .

Summary: Tissue Location: Retina and pineal gland.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Recoverin, Cancer-associated retinopathy protein, Protein CAR, RCVRN, RCV1