Remodelin | 9411

Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduces the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin has no effect on nonlaminopathic Werner syndrome cells.

Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduces the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin has no effect on nonlaminopathic Werner syndrome cells.

9411 | Remodelin DataSheet

Alternate Name/Synonyms: 4-​[2-​(2-​cyclopentylidenehydrazinyl)-​4-​thiazolyl]-​benzonitrile

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 949912-58-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₄N₄S

Molecular Weight: 282.36

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A N-acetyltransferase 10 (NAT10) inhibitor

MDL Number: N/A

PubChem CID: 44442376

SMILES: C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1

InChi: InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19)

InChi Key: XAEJIFARBQJLML-UHFFFAOYSA-N