Resatorvid | B3347

Resatorvid | B3347

Description: Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Also inhibits autophagy.

Alternate Name/Synonyms: ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate CLI-095 TAK-242

Appearance: Solid

Formulation:

CAS Number: 243984-11-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₇ClFNO₄S

Molecular Weight: 361.82

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by axposure.

Tag Line: A selective Toll-like receptor 4 (TLR4) inhibitor

MDL Number:

PubChem CID: 11703255

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/11703255

SMILES: CCOC(=O)C1=CCCCC1S(=O)(=O)NC2=C(C=C(C=C2)F)Cl

InChi: InChI=1S/C15H17ClFNO4S/c1-2-22-15(19)11-5-3-4-6-14(11)23(20,21)18-13-8-7-10(17)9-12(13)16/h5,7-9,14,18H,2-4,6H2,1H3/t14-/m1/s1

InChi Key: LEEIJTHMHDMWLJ-CQSZACIVSA-N

Category: Biochemicals