Resminostat (hydrochloride) | B2852

Resminostat is a potent inhibitor of histone deacetylases (HDAC) 1, 3 and 6 with IC₅₀ ranging from 43–72 nM. It induces hyperacetylation of histone H4, abrogates cell growth and induces apoptosis in multiple myeloma cells with an IC₅₀ of 2.5-3 µM. It inhibits cell proliferation, induces G0/G1 cell cycle arrest, decreases levels of cyclin D1, cdc25a, Cdk4 and pRb and upregulates p21.

Resminostat is a potent inhibitor of histone deacetylases (HDAC) 1, 3 and 6 with IC₅₀ ranging from 43–72 nM. It induces hyperacetylation of histone H4, abrogates cell growth and induces apoptosis in multiple myeloma cells with an IC₅₀ of 2.5-3 µM. It induces G0/G1 cell cycle arrest, decreases levels of cyclin D1, cdc25a, Cdk4 and pRb and upregulates p21.

B2852 | Resminostat (hydrochloride) DataSheet

Alternate Name/Synonyms: 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide, monohydrochloride; 4SC-201 hydrochloride; RAS2410 hydrochloride; (E)-3-[1-(4-dimethylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-N-hydroxy-acrylamide hydrochloride

Appearance: Crystalline solid

Formulation:

CAS Number: 1187075-34-8

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₁₆H₂₀ClN₃O₄S

Molecular Weight: 385.87

Cell-Permeable?: True

Purity: >98% (HPLC)

Solubilities: ~0.5 mg/ml in PBS, pH 7.2 in 0, ~10 mg/ml in in DMSO, ~0.5 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of HDAC

MDL Number:

PubChem CID: 16662815

SMILES: CN(C)CC1=CC=C(C=C1)S(=O)(=O)N2C=CC(=C2)C=CC(=O)NO.Cl

InChi: InChI=1S/C16H19N3O4S.ClH/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21;/h3-10,12,21H,11H2,1-2H3,(H,17,20);1H/b8-5+;

InChi Key: BVXPKDRKHXARHY-HAAWTFQLSA-N