RET monoclonal Antibody | MB64892

RET monoclonal Antibody | MB64892 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Rat

Application: IHC, WB

Application Range: IHC 1:150

Background: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: ret proto-oncogene

Molecular Weight: 124.1 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51

Immunogen: Human recombinant protein fragment corresponding to amino acids 713-1017 of human RET (NP_066124) produced in E.coli.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A