Retinoic acid | 2218

Retinoic acid is a metabolite of vitamin A that acts as a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RAR and RXR heterodimerize and act as ligand-dependent transcriptional regulators, with roles in development, reproduction, immunity, organogenesis, and cancer. Retinoic acid primes embryonic stem cells to become neurons.

Retinoic acid is a metabolite of vitamin A that acts as a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RAR and RXR heterodimerize and act as ligand-dependent transcriptional regulators, with roles in development, reproduction, immunity, organogenesis, and cancer. Retinoic acid primes embryonic stem cells to become neurons.

2218 | Retinoic acid DataSheet

Alternate Name/Synonyms: ATRA; Tretinoin; NSC 122758; Vitamin A Acid; all-trans Retinoic Acid; NSC 122578

Appearance: Yellow solid with an orange tinge

Formulation: N/A

CAS Number: 302-79-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₈O₂

Molecular Weight: 300.44

Cell-Permeable?: Yes

Purity: ≥98% by titration

Solubilities: DMSO (20 mg/ml) or Ethanol (0.5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A retinoic acid receptor (RAR) and the retinoid X receptor (RXR) ligand

MDL Number: MFCD00001551

PubChem CID: 444795

SMILES: CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

InChi: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

InChi Key: SHGAZHPCJJPHSC-YCNIQYBTSA-N