Reversine | 1851

A cell-permeable, potent, and selective human A3 adenosine receptor antagonist (Ki = 0.66 μM) and an aurora kinase inhibitor (IC₅₀'s of 30-550 nM for blast colony formation assay). Induces dedifferentiation in murine C2C12 myoblasts. The cells were also shown to regain multipluripotency following removal of the compound.

Reversine is a cell-permeable, potent, and selective human A3 adenosine receptor antagonist (Ki = 0.66 μM) and an aurora kinase inhibitor (IC₅₀'s of 30-550 nM for blast colony formation assay). Induces dedifferentiation in murine C2C12 myoblasts.

1851 | Reversine DataSheet

Alternate Name/Synonyms: 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 656820-32-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₇N₇O

Molecular Weight: 393.49

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~7-10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An A3 adenosine receptor antagonist

MDL Number: MFCD07784513

PubChem CID: 210332

SMILES: C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5

InChi: InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)

InChi Key: ZFLJHSQHILSNCM-UHFFFAOYSA-N