RGS20 Antibody (Center) [AMM07590G]

RGS20 Antibody (Center) [AMM07590G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RGS20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 150-184 amino acids from the Central region of human RGS20.

Cellular Localisation: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation.

Molecular Weight: 43692

Clone: Polyclonal

Gene Name: RGS20

Gene ID: 8601

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G (z) -alpha and G (alpha) - i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G (z) -alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity) .

Summary: Tissue Location: Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Regulator of G-protein signaling 20, RGS20, Gz-selective GTPase-activating protein, G (z) GAP, Gz-GAP, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1, RGS20, RGSZ1, ZGAP1