RGS20 polyclonal Antibody | BS60230

RGS20 polyclonal Antibody | BS60230 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a subunits) thereby driving G proteins into their inactive GDP-bound form. RGS20 is expressed exclusively in brain, with highest levels in the caudate nucleus and temporal lobe. RGS20 belongs to the RZ subfamily because it is highly selectivie for the az subunit on G proteins. However, if protein kinase C phosphorylates the az subunit, the G protein is much less susceptible to RGS20 action. RGS20 directly interacts with the microtubule-destabilizing protein SCG10 (superior cervical ganglia, neural specific 10) and blocks its ability to induce microtubule disassmebly.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RGS20 polyclonal Antibody detects endogenous levels of RGS20 protein.

Molecular Weight: ~ 30 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Regulator of G-protein signaling 20; Gz-selective GTPase-activating protein; G (z) GAP; Gz-GAP; Regulator of G-protein signaling Z1; Regulator of Gz-selective protein signaling 1; RGSZ1; ZGAP1

Immunogen: A synthetic peptide corresponding to residues in Human RGS20.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: