Riluzole | B3068

Riluzole is a benzothiazole derivative which inhibits glutamatergic neurotransmission and blocks voltage-dependent sodium channels (ED₅₀ = 2.3 μM). It reduces the uptake of GABA from neuronal synapse. Riluzole suppresses glutamate-induced seizures in rats with an ED₅₀ value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals with an ED₅₀ value of 4 mg/kg. It is used for the treatment of amyotrophic lateral sclerosis.

Riluzole is a benzothiazole derivative which inhibits glutamatergic neurotransmission and blocks voltage-dependent sodium channels (ED₅₀ = 2.3 μM). It reduces the uptake of GABA from neuronal synapse. Riluzole suppresses glutamate-induced seizures in rats with an ED₅₀ value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals with an ED₅₀ value of 4 mg/kg. It is used for the treatment of amyotrophic lateral sclerosis.

B3068 | Riluzole DataSheet

Alternate Name/Synonyms: Rilutek; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine; 2-Amino-6-(trifluoromethoxy)benzothiazole; 6-(trifluoromethoxy)benzo[d]thiazol-2-amine

Appearance: White to light yellow powder

Formulation:

CAS Number: 1744-22-5

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₈H₅F₃N₂OS

Molecular Weight: 234.2

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~25 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of glutamatergic neurotransmission

MDL Number: MFCD00210213

PubChem CID: 5070

SMILES: C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N

InChi: InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)

InChi Key: FTALBRSUTCGOEG-UHFFFAOYSA-N