RIPK3 polyclonal Antibody | BS7363

RIPK3 polyclonal Antibody | BS7363 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: The death domain is a cytoplasmic domain of approximately 80 amino acids that is necessary for the transduction of apoptotic signals and is present in the apoptosis-mediating receptors TNF-R1 and FAS. Other death domain-containing, but otherwise structurally unrelated proteins have been identified on the basis of their ability to associate with the cytoplasmic domains of TNF-R1 or FAS. One of these proteins, the receptor-interacting protein 3 (RIP3), contains an N-terminal kinase domain and shares extensive homology with RIP and RIP2. However, RIP3 contains a unique C-terminal death domain, which promotes apoptosis. RIP3 can be expressed as two splice variants, RIP3β and RIP3γ, which contain a truncated N-terminal kinase domain and a distinct and shorter C-terminus. Subsequently, expression of these splice variants downregulates RIP3-mediated apoptosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: RIP3 polyclonal Antibody detects endogenous levels of Receptor-interacting serine/threonine-protein kinase 3 protein.

Molecular Weight: ~ 45-70 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Receptor-interacting serine/threonine-protein kinase 3; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; RIPK3; RIP3

Immunogen: Recombinant full length Human RIP3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: