Description
Ritonavir is an orally bioavailable HIV-1 and HIV-2 protease inhibitor (EC₅₀ values are 0.022-0.13 and 0.16 μM, respectively). Through CYP3A4 inhibition, low doses of ritonavir can reduce the metabolism of concomitantly administered protease inhibitors, enhancing their bioavailability and efficacy.
Ritonavir is an orally bioavailable HIV-1 and HIV-2 protease inhibitor (EC₅₀ values are 0.022-0.13 and 0.16 μM, respectively). Through CYP3A4 inhibition, low doses of ritonavir can reduce the metabolism of concomitantly administered protease inhibitors, enhancing their bioavailability and efficacy.
Alternate Name/Synonyms: (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl ester; ABT-538; NSC 693184
Appearance: White solid
Formulation: N/A
CAS Number: 155213-67-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₇H₄₈N₆O₅S₂
Molecular Weight: 720.94
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml with slight warming)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An orally bioavailable HIV-1 and HIV-2 protease inhibitor
MDL Number: MFCD00927142
PubChem CID: 392622
SMILES: CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
InChi: InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
InChi Key: NCDNCNXCDXHOMX-XGKFQTDJSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |