RNF19A Antibody (Center) [APR13132G]

RNF19A Antibody (Center) [APR13132G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A.

Cellular Localisation: Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients

Molecular Weight: 90696

Clone: Polyclonal

Gene Name: RNF19A

Gene ID: 25897

Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.

Summary: Tissue Location: Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: E3 ubiquitin-protein ligase RNF19A, 632-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19