RNF4 Antibody [AMM22286G]

RNF4 Antibody [AMM22286G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This RNF4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human RNF4.

Cellular Localisation: Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm

Molecular Weight: 21319

Clone: Monoclonal

Gene Name: RNF4

Gene ID: 6047

Function: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Summary: Tissue Location: Widely expressed at low levels in many tissues; highly expressed in testis.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: E3 ubiquitin-protein ligase RNF4, 6.3.2.-, RING finger protein 4, Small nuclear ring finger protein, Protein SNURF, RNF4, SNURF