RO 20-1724 | 2042

Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

ARO 20-1724 is a potent, selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

2042 | RO 20-1724 DataSheet

Alternate Name/Synonyms: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 29925-17-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₂N₂O₃

Molecular Weight: 278.35

Cell-Permeable?: Yes

Purity: ≥99% by TLC

Solubilities: DMSO (~200 mg/ml) or Ethanol (~40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PDEIV inhibitor

MDL Number: MFCD00077397

PubChem CID: 5087

SMILES: CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC

InChi: InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)

InChi Key: PDMUULPVBYQBBK-UHFFFAOYSA-N