ROBO1 Antibody (C-Term) [APR33403G]

ROBO1 Antibody (C-Term) [APR33403G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ROBO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1097-1130 amino acids from human ROBO1.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:O89026}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:O55005}; Single-pass membrane protein {ECO:0000250|UniProtKB:O55005} Note=Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity) . PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity) {ECO:0000250|UniProtKB:O55005, ECO:0000250|UniProtKB:O89026}

Molecular Weight: 180930

Clone: Polyclonal

Gene Name: ROBO1

Gene ID: 6091

Function: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577) . Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577) . In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity) . Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257) . May be required for lung development (By similarity) .

Summary: Tissue Location: Widely expressed, with exception of kidney.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000-1:2000

Synonyms: Roundabout homolog 1, Deleted in U twenty twenty, H-Robo-1, ROBO1, DUTT1