RUNX1T1 (ETO) monoclonal Antibody | MB65003

RUNX1T1 (ETO) monoclonal Antibody | MB65003 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IF, WB

Application Range: WB 1:2000, IF 1:100

Background: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: RUNX1 translocation partner 1

Molecular Weight: 63 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2

Immunogen: Full length human recombinant protein of human RUNX1T1 (NP_783553) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A