S-Adenosyl-L-methionine disulfate tosylate | 2077

A methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.

S-Adenosyl-L-methionine disulfate tosylate is a methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.

2077 | S-Adenosyl-L-methionine disulfate tosylate DataSheet

Alternate Name/Synonyms: AdoMet SAM disulfate p-toluenesulfonate; SAMe

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 97540-22-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₅H₂₂N₆O₅S.C₇H₁₂O₁₁S₂

Molecular Weight: 766.8

Cell-Permeable?: No

Purity: ≥95% by HPLC

Solubilities: H₂O (~100 mg/ml)

Handling: Protect from moisture

Country of Origin: USA

Tag Line: A cofactor for catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT)

MDL Number: MFCD01674068

PubChem CID: 163657

SMILES: CC1=CC=C(C=C1)S(=O)(=O)[O-].C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C2N= CN=C3N)O)O.OS(=O)(=O)[O-].[O-]S(=O)(=O)[O-]

InChi: InChI=1S/C15H22N6O5S.C7H8O3S.2H2O4S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11 (23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8, 9)10;2*1-5(2,3)4/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24, 25);2-5H,1H3,(H,8,9,10);2*(H2,1,2,3,4)/p-3/t7-,8+,10+,11+,14+, 27?;;;/m0.../s1

InChi Key: XDCFCHNAIMYBAZ-XQVUROGGSA-K