S100A1 Antibody (C-term) [APR13180G]

S100A1 Antibody (C-term) [APR13180G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This S100A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-75 amino acids from the C-terminal region of human S100A1.

Cellular Localisation: Cytoplasm. Sarcoplasmic reticulum. Mitochondrion {ECO:0000250|UniProtKB:P56565}

Molecular Weight: 10546

Clone: Polyclonal

Gene Name: S100A1

Gene ID: 6271

Function: Small calcium binding protein that plays important roles in several biological processes such as Ca (2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600) . In response to an increase in intracellular Ca (2+) levels, binds calcium which triggers conformational changes (PubMed:23351007) . These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290) . Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca (2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca (2+) -ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600) . Facilitates diastolic Ca (2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446) .

Summary: Tissue Location: Highly prevalent in heart (PubMed:12804600, PubMed:1384693) . Also found in lesser quantities in skeletal muscle and brain (PubMed:1384693) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100A1, S100A