SA4503 dihydrochloride | B3046

SA4503 is a potent sigma-1 (σ1 receptor) agonist. It shows 100 fold higher affinity for σ1 than σ2 receptor with IC₅₀ values of 17.4 nM and 1784 nM against 200 nM (+)-pentazocine for binding σ receptor in guinea pig brain membranes. It shows Ki values of 4.6 nM and 63.1 nM for σ1 and σ2 sites respectively in guinea pig brain homogenates. It enhances recovery of lost sensorimotor function in a rat model of stroke. Based on viral screens, modulators of sigma receptor are predicted to show activity against SARS-CoV-2.

SA4503 is a potent sigma-1 (σ1 receptor) agonist. It shows 100 fold higher affinity for σ1 than σ2 receptor with IC₅₀ values of 17.4 nM and 1784 nM against 200 nM (+)-pentazocine for binding σ receptor in guinea pig brain membranes. It shows Ki values of 4.6 nM and 63.1 nM for σ1 and σ2 sites respectively in guinea pig brain homogenates. It enhances recovery of lost sensorimotor function in a rat model of stroke. Based on viral screens, modulators of sigma receptor are predicted to show activity against SARS-CoV-2.

B3046 | SA4503 dihydrochloride DataSheet

Alternate Name/Synonyms: Cutamesine dihydrochloride; 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride; 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine 2HCl; AGY94806 dihydrochloride

Appearance: White to Off-White Solid

Formulation:

CAS Number: 165377-44-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₂₃H₃₄Cl₂N₂O₂

Molecular Weight: 441.43

Cell-Permeable?: FALSE

Purity: ≥98%

Solubilities: ~5 mg/ml in PBS, pH 7.2; ~2 mg/ml in water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: a potent sigma-1 (σ1 receptor) agonist

MDL Number: MFCD00939308

PubChem CID: 9954941

SMILES: COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC.Cl.Cl

InChi: InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H

InChi Key: XWOXAKBQEMQMFH-UHFFFAOYSA-N