SANT-1 | 1978

Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC₅₀of 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.

SANT-1 is a potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC₅₀of 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.

1978 | SANT-1 DataSheet

Alternate Name/Synonyms: N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4- (phenylmethyl)-1-piperazinamine

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 304909-07-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₇N₅

Molecular Weight: 373.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~50 mM) or EtOH (~25 mM)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent inhibitor of Sonic hedgehog (Shh) signaling

MDL Number: MFCD01827306

PubChem CID: 6878030

SMILES: CC1=C(C(=NN1C2=CC=CC=C2)C)C=NN3CCN(CC3)CC4=CC=CC=C4

InChi: InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+

InChi Key: FOORCIAZMIWALX-JJIBRWJFSA-N