Saquinavir . mesylate | 10-044

Saquinavir . mesylate | 10-044 | Gentaur UK, US & Europe Distribution

BNR: Chemical

Predicted Molecular Weight: 670.9 . 96.1

Physical State: Lyophilized

Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Alternate Name: Ro 31-8959

Background: Saquinavir is an antiretroviral inhibitor of the human immunodeficiency virus. It potently inhibits HIV-1 (Ki=0.12nM) and HIV-2 (Ki<0.1nM) protease in vitro. HIV-1 protease is important for the replication of the virus within the cell and the release of mature viral particles from the infected cell. Formulations containing saquinavir have been used in combination with other inhibitors for the treatment of AIDS. Saquinavir shows other antimicrobial and antiviral activity. Potential SARS-CoV-2 replication inhibitor, responsible for COVID-19. Shows anti-cancer activity. Shown to induce apoptosis, autophagy and endoplasmic reticulum stress, which consequently leads to cancer cell death. Anti-inflammatory agent. Blocks cathepsin V and thereby inhibits disulfide HMGB1-induced TLR4 activation and cytokine production.

Disclaimer: This product is for research use only.

Purity: greater than or equal to 98%

Formula: C38H50N6O5 . CH4SO3

Source: N/A

Solubility: Soluble in DMSO or DMF. Sparingly soluble in ethanol, methanol or water.

InChi Key: IRHXGOXEBNJUSN-YOXDLBRISA-N

Smiles: CS (=O) (O) =O.O[C@@H] ([C@@H] (NC ([C@H] (CC (N) =O) NC (C1=NC (C=CC=C2) =C2C=C1) =O) =O) CC3=CC=CC=C3) CN4C[C@@]5 ([H]) CCCC[C@@]5 ([H]) C[C@H]4C (NC (C) (C) C) =O

RTECS: EJ6664000

Identity: Determined by 1H-NMR.

Merck Index: N/A