SAR-131675 | B2592

SAR-131675 is a potent and specific VEGFR-3 inhibitor. It inhibits VEGFR-3 tyrosine kinase activity (IC₅₀ = 20 nmol/L) and VEGFR-3 autophosphorylation (IC₅₀ = 5 nmol/L) in HEK cells, respectively. SAR-131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 displays antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.

SAR-131675 is a potent and specific VEGFR-3 inhibitor. It inhibits VEGFR-3 tyrosine kinase activity (IC₅₀ = 20 nmol/L) and VEGFR-3 autophosphorylation (IC₅₀ = 5 nmol/L) in HEK cells, respectively. SAR-131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 displays antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.

B2592 | SAR-131675 DataSheet

Alternate Name/Synonyms: SAR 131675, SAR131675, 2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Appearance: Crystalline solid

Formulation:

CAS Number: 1092539-44-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₂N₄O₄

Molecular Weight: 358.40

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective VEGFR-3 inhibitor

MDL Number:

PubChem CID: 67081200

SMILES: CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#CC(C)(COC)O)C(=O)NC)N

InChi: InChI=1S/C18H22N4O4/c1-5-22-15(19)13(17(24)20-3)14(23)12-7-6-11(21-16(12)22)8-9-18(2,25)10-26-4/h6-7,25H,5,10,19H2,1-4H3,(H,20,24)

InChi Key: