SARS-CoV-2 (COVID-19) Nucleocapsid Antibody [14B2D] | 10-609

SARS-CoV-2 (COVID-19) Nucleocapsid Antibody [14B2D] | 10-609 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Virus

Homology: N/A

Immunogen: N/A

Research Area: Infectious Disease, COVID-19

Tested Application: WB, E

Application: WB (1:500-2000) , ELISA (1:500-1000)

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Purified by Protein G.

Clonality: Monoclonal

Clone: 14B2D

Isotype: IgG2b

Conjugate: Unconjugated

Physical State: Liquid

Buffer: 0.01M PBS (pH7.4) with 0.1% Proclin300

Concentration: ≥1 mg/mL

Storage Condition: Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze-thaw cycles.

Alternate Name: SARS-CoV-2 Nucleocapsid Protein, SARS-CoV-2 NP, nucleocapsid protein [Severe acute respiratory syndrome coronavirus 2], novel coronavirus N Protein, novel coronavirus Nucleocapsid Protein, 2019-nCoV Nucleoprotein, 2019-nCoV N, 2019nCoV N, 2019-nCoV N Protein, 2019 peak N Protein, 2019-nCoV nucleocapsid protein.

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.