SARS-CoV-2 (COVID-19) Spike L452R Antibody (Delta Variant) | 9463

SARS-CoV-2 (COVID-19) Spike L452R Antibody (Delta Variant) | 9463 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Virus

Homology: Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins: (77.8%)

Immunogen: Anti-SARS-CoV-2 Spike L452R (Delta Variant) antibody (9463) was raised against a peptide corresponding to 9 amino acids in the receptor binding domain of SARS-CoV-2 Delta variant (B.1.617.2) Spike protein.
The immunogen is located within 430-480 amino acids of SARS-CoV-2 Delta variant (B.1.617.2) Spike protein.

Research Area: Infectious Disease, COVID-19

Tested Application: E, WB

Application: WB: 1 μg/mL.
Antibody validated: Western Blot in human samples. Anti-SARS-CoV-2 Spike L452R (Delta Variant) antibody specifically detects SARS-CoV-2 Delta Variant (B.1.617.2) Spike S1 protein, but not SARS-CoV-2 WT and other variant Spike S1 proteins by ELISA. All other applications and species not yet tested.

Specificiy: It can only detect SARS-CoV-2 Delta Variant (B.1.617.2) Spike S1 protein and does not cross-react with the spike protein of other variants.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Anti-SARS-CoV-2 Spike Delta Variant antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: SARS-CoV-2 Spike Delta Variant antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: SARS-CoV-2 Spike Delta Variant antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: SARS-CoV-2 Spike 156-157EF antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) , Surface Glycoprotein, Spike protein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: SARS-CoV-2 delta variant, a variant of concern (VOC) , known as B.1.617.2, was detected in India in October of 2020. However, it rapidly spread all over of the world and now it is the dominant variant in the world, which account for more than 99% of the cases. This variant carries at least 13 mutations in spike protein across the sub lineages, including L452R, D614G, P681R and K417N, which can increase the affinity to the human ACE2 receptor. Enhanced transmission of the Delta variant was observed globally, which is at least 2.5 times more contagious as the other variants. The Delta variant affects the effectiveness of COVID19 vaccine and is resistant to neutralization to some extent.