SARS-CoV-2 Spike RBD Antibody, monoclonal, Chimeric | 11-582

SARS-CoV-2 Spike RBD Antibody, monoclonal, Chimeric | 11-582 | Gentaur UK, US & Europe Distribution

Host: N/A

Reactivity: Mouse

Homology: N/A

Immunogen: Anti-SARS-CoV-2 Spike RBD Antibody, Human IgM is a chimeric monoclonal antibody combining the constant domains of the human IgM molecule with mouse variable regions.

Research Area: Infectious Disease, COVID-19

Tested Application: E, WB

Application: N/A

Specificiy: This product can recognize SARS-CoV-2 and SARS-CoV Spike Protein RBD domainn. No cross-reactivity is detected with Spike Protein RBD domain of other coronaviruses, including MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: >85% as determined by SDS-PAGE.

Clonality: Recombinant Monoclonal

Clone: N/A

Isotype: Human IgM | Kappa

Conjugate: Unconjugated

Physical State: Lyophilized

Buffer: Lyophilized from 0.22 ����m filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.

Concentration: batch dependent

Storage Condition: For long term storage, the product should be stored at lyophilized state at -20˚C or lower..Please avoid repeated freeze-thaw cycles.This product is stable after storage at:.-20 to -70˚C for 12 months in lyophilized state from date of receipt;.-70˚C for 3 months under sterile conditions after reconstitution.

Alternate Name: spike glycoprotein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD) , which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.