SATB2 polyclonal Antibody | BS65709

SATB2 polyclonal Antibody | BS65709 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Cow,Horse,Sheep,

Application: FCM,

Application Range: Flow-Cyt=1ug/test

Background: SATB2 is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SATB2 Polyclonal Antibody detects endogenous levels of SATB2 protein.

Molecular Weight: 83kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DNA binding protein SATB2; DNA-binding protein SATB2; FLJ21474; FLJ32076; KIAA1034; MGC119474; MGC119477; SATB family member 2; SATB homeobox 2; SATB2; SATB2_HUMAN; Special AT rich sequence binding protein 2; Special AT-rich sequence-binding protein 2.  

Immunogen: KLH conjugated synthetic peptide derived from human SATB2:451-485/733

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: