SATB2 polyclonal Antibody | BS91209

SATB2 polyclonal Antibody | BS91209 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC FC

Application Range: WB:1:500-1:1,000 ICC/IF:1:50-1:100 IHC:1:50-1:200 FC:1:50-1:100

Background: SATB2 (Special AT-rich sequence-binding protein 2) is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SATB2 polyclonal Antibody detects endogenous levels of SATB2 protein.

Molecular Weight: N/A

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SATB2, KIAA1034, DNA binding protein SATB2, DNA-binding protein SATB2, FLJ21474, FLJ32076, GLSS, KIAA1034, MGC119474, MGC119477, SATB family member 2, SATB homeobox 2, SATB2, SATB2, Special AT rich sequence binding protein 2, Special AT-rich sequence-binding protein 2,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: