SB 202190 | 2493

SB 202190 is a highly selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively. At higher concentrations (10 µM), SB 202190 displays negligible effects on several other kinases including other MAP kinases (ERKs, JNKs).

SB 202190 is a highly selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively. At higher concentrations (10 µM), SB 202190 displays negligible effects on several other kinases including other MAP kinases (ERKs, JNKs).

2493 | SB 202190 DataSheet

Alternate Name/Synonyms: 4-​[4-​(4-​fluorophenyl)-​5-​(4-​pyridinyl)-​1H-​imidazol-​2-​yl]-​phenol

Appearance: Off-white solid

Formulation: N/A

CAS Number: 152121-30-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C20H14FN3O

Molecular Weight: 331.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective MAP Kinase inhibitor

MDL Number: MFCD00941964

PubChem CID: 5353940

SMILES: C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

InChi: InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H

InChi Key: NJNKPVPFGLGHPA-UHFFFAOYSA-N