SB 203580 | 1712

Cell-permeable. Selective inhibitor of p38 mitogen-activated protein kinase (MAP Kinase) (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα.

SB 203580 is a selective inhibitor of p38 mitogen-activated protein kinase (MAP Kinase) (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα.

1712 | SB 203580 DataSheet

Alternate Name/Synonyms: [4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 152121-47-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₆FN₃OS

Molecular Weight: 377.43

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (>50 mg/ml) or warm ethanol (12 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A MAP Kinase inhibitor

MDL Number: MFCD00922198

PubChem CID: 176155

SMILES: CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

InChi: InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

InChi Key: CDMGBJANTYXAIV-UHFFFAOYSA-N