SB-415286 | B1954

SB-415286 is a potent, selective and ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α). Displays minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

SB-415286 is a potent, selective and ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α). Displays minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

B1954 | SB-415286 DataSheet

Alternate Name/Synonyms: 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione

Appearance: Yellow solid

Formulation: N/A

CAS Number: 264218-23-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₀ClN₃O₅

Molecular Weight: 359.73

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective and ATP-competitive, glycogen synthase kinase-3 (GSK-3) inhibitor

MDL Number: MFCD04039789

PubChem CID: 4210951

SMILES: C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

InChi: InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

InChi Key: PQCXVIPXISBFPN-UHFFFAOYSA-N