SELK Antibody (Center) [APR14401G]

SELK Antibody (Center) [APR14401G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This SELK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the Central region of human SELK.

Cellular Localisation: Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Probably mainly localized in the ER

Molecular Weight: 10645

Clone: Polyclonal

Gene Name: SELENOK {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:30394}

Gene ID: 58515

Function: Required for Ca (2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity) . Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385) . Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity) . Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151) . Plays a role in protection of cells from ER stress- induced apoptosis (PubMed:20692228) . Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588) .

Summary: Tissue Location: Highly expressed in heart.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:500

Synonyms: Selenoprotein K, SelK, SELK