Selpercatinib | B2996

Selpercatinib is a RET kinase inhibitor with IC₅₀ values ranging from 1 nM to 4 nM for wild type and mutant RET kinase. It has shown promising results in early phase clinical trials for RET-driven lung tumours with enhanced clinical activity and better tolerability.

Selpercatinib is a RET kinase inhibitor with IC₅₀ values ranging from 1 nM to 4 nM for wild type and mutant RET kinase. It has shown promising results in early phase clinical trials for RET-driven lung tumours with enhanced clinical activity and better tolerability.

B2996 | Selpercatinib DataSheet

Alternate Name/Synonyms: 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile; LOXO-292

Appearance: White to off-White powder

Formulation:

CAS Number: 2152628-33-4

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₉H₃₁N₇O₃

Molecular Weight: 525.6

Cell-Permeable?: True

Purity: >98%

Solubilities: ~8 mg/ml in DMSO. Ultrasonication can be done to improve solubility.

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A RET kinase inhibitor

MDL Number:

PubChem CID: 134436906

SMILES: CC(C)(COC1=CN2C(=C(C=N2)C#N)C(=C1)C3=CN=C(C=C3)N4CC5CC(C4)N5CC6=CN=C(C=C6)OC)O

InChi: InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3

InChi Key: XIIOFHFUYBLOLW-UHFFFAOYSA-N