SEMA4D Antibody (Center) [APR13249G]

SEMA4D Antibody (Center) [APR13249G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SEMA4D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 553-587 amino acids from the Central region of human SEMA4D.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 96150

Clone: Polyclonal

Gene Name: SEMA4D

Gene ID: 10507

Function: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282) . Regulates GABAergic synapse development (By similarity) . Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity) . Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569) . Promotes the migration of cerebellar granule cells (PubMed:16055703) . Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214) . Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703) .

Summary: Tissue Location: Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Semaphorin-4D, A8, BB18, GR3, CD100, SEMA4D, C9orf164, CD100, SEMAJ