SEPT5 Antibody | 14-722

SEPT5 Antibody | 14-722 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human SEPT5 (NP_002679.2) .

Research Area: Cell Cycle, Chemokines & Cytokines, Immunology, Neuroscience, Signal Transduction

Tested Application: WB, IHC

Application: WB: 1:500 - 1:2000
IHC: 1:100 - 1:200

Specificiy: N/A

Positive Control 1: Jurkat

Positive Control 2: NIH/3T3

Positive Control 3: Mouse brain

Positive Control 4: Mouse heart

Positive Control 5: Mouse kidney

Positive Control 6: Rat brain

Molecular Weight: Observed: 43kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: SEPT5, CDCREL-1, CDCREL1, H5, HCDCREL-1, Peanut-like 1 (Drosophila) , Peanut-like 1, Peanut-like protein 1, Septin 5, Septin-5, CDCREL, PNUTL1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) , whereby larger, non-coding transcripts are produced.