Septin 6 polyclonal Antibody | BS5925

Septin 6 polyclonal Antibody | BS5925 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Septin 6, also known as SEPT6, is a 434 amino acid protein that belongs to the septin family. The highly conserved septin family of GTP-binding cytoskeletal proteins is implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis and other cellular functions. Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. Filaments are assembled from asymmetrical heterotrimers, composed of Septin 2, Septin 6 and Septin 7 that associate head-to-head to form a hexameric unit, however interaction with Septin 12 alters filament structure. Septin 6 shares 40% identity with CDC10 and contains an ATP/GTP-binding site motif. The Septin 6 protein demonstrates nearly ubiquitous expression, with highest level in thymus. The Septin 6 protein is phosphorylated upon DNA damage, probably by Atm or ATR.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Septin 6 polyclonal Antibody detects endogenous levels of Septin 6 protein.

Molecular Weight: ~ 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Septin6; Septin-6; SEPT6; KIAA0128; SEP2

Immunogen: Synthetic peptide, corresponding to amino acids 267-312 of Human Septin 6.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: