SERCA1 ATPase polyclonal Antibody | BS91222

SERCA1 ATPase polyclonal Antibody | BS91222 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IP IHC

Application Range: WB:1:500-1:1,000 IP:1:10-1:50 IHC:1:50-1:200

Background: This gene encodes one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. There are 3 major domains on the cytoplasmic face of SERCA: the phosphorylation and nucleotide-binding domains, which form the catalytic site, and the actuator domain, which is involved in the transmission of major conformational changes. It seems that, in addition to the calcium-transporting properties, SERCA1 generates heat in some adipocytes [1][2] and can improve cold tolerance in some wood frogs.

Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Specificity: SERCA1 ATPase polyclonal Antibody detects endogenous levels of SERCA1 ATPase protein.

Molecular Weight: 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SERCA1, SR Ca (2+) -ATPase 1, ATP2A1, fast twitch skeletal muscle isoform, AT2A1, ATP2A, ATP2A1, ATPase Ca++ transporting cardiac muscle fast twitch 1, ATPase Ca++ transporting fast twitch 1, ATPase, Ca (2+) -transporting fast twitch 1, Calcium pump 1, Calcium transporting ATPase sarcoplasmic reticulum type fast twitch skeletal muscle isoform, Calcium-transporting ATPase sarcoplasmic reticulum type, EC 3.6.3.8, Endoplasmic reticulum class 1/2 Ca (2+) ATPase, Fast skeletal muscle SR calcium ATPase, OTTHUMP00000162561, OTTHUMP00000162562, Sarcoendoplasmic reticulum calcium ATPase, Sarcoplasmic reticulum Ca (2+) -ATPase 1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, SERCA 1, SERCA1, SERCA1 truncated isoform, included, SR Ca (2+) ATPase 1, SR Ca (2+) -ATPase 1 Antibody

Immunogen: Synthetic peptide within human SERCA1 ATPase aa 1-50.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A purified.

Pathway: