SERPINB7 polyclonal Antibody | BS5794

SERPINB7 polyclonal Antibody | BS5794 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivate MMP-2, MMP-9 and plasmin, proteins that are notably responsible for degradation of extracellular matrix. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SERPINB7 polyclonal Antibody detects endogenous levels of SERPINB7 protein.

Molecular Weight: ~ 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Serpin B7; Serpin-B7; Megsin; TP55

Immunogen: Synthetic peptide, corresponding to amino acids 157-202 of Human SERPINB7.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A