Sestrin-1 Antibody (N-term) [APR07173G]

Sestrin-1 Antibody (N-term) [APR07173G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This Sestrin-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human Sestrin-1.

Cellular Localisation: Nucleus. Cytoplasm

Molecular Weight: 56557

Clone: Polyclonal

Gene Name: SESN1 (HGNC:21595)

Gene ID: 27244

Function: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471) . This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity) . May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085) . Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity) . Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503) . However, this could not be confirmed (By similarity) .

Summary: Tissue Location: Widely expressed..

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Sestrin-1, p53-regulated protein PA26, SESN1, PA26, SEST1