SF1 polyclonal Antibody | GCP58

SF1 polyclonal Antibody | GCP58 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC

Application Range: WB: 1:1000~1:2000 IHC: 1:50~1:200

Background: Mammalian splicing factor 1 (designated SF1, zinc finger protein 162, ZFM1,CW17R and mammalian branch point binding protein [mBBP]) specificallyrecognizes the seven-nucleotide branch point sequence located at 3' splicesites and participates in the assembly of early spliceosomal complexes.Splicing factor 1 functions as a transcriptional repressor and may control bothproliferation and expression of pro-inflammatory gene products in smoothmuscle cells. In addition, cytokine-induced downregulation of splicing factor 1 expression may contribute to the pathogenesis of hyperproliferative inflammatory diseases. The structure of splicing factor 1 contains a nuclear transport domain, a metal binding motif, and glutamine- and proline-rich regions.Human splicing factor 1 also exists as several different isoforms, H1-isoformand Bo-isoform, produced by alternative splicing events. The human splicingfactor 1 gene is located on chromosome 11 close to the gene encoding Menin,the gene responsible for multiple endocrine neoplasia-type 1 (MEN1) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SF1 polyclonal Antibody detects endogenous levels of SF1 protein.

Molecular Weight: ~ 75 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Splicing factor 1; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162; SF1; ZFM1; ZNF162

Immunogen: Synthetic peptide, corresponding to Human SF1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A