SF3B3 Polyclonal Antibody | E-AB-40212

SF3B3 Polyclonal Antibody | E-AB-40212 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: KIAA0017, Pre mRNA splicing factor SF3b 130 kDa subunit, Pre-mRNA-splicing factor SF3b 130 kDa subunit, RSE1, SAP 130, SAP130, SF3b130, SF3B3, SF3B3_HUMAN, Spliceosome associated protein 130, Spliceosome-associated protein 130, Splicing factor 3b subunit 3 130kD, Splicing factor 3B subunit 3, STAF130

Application: IHC

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Epigenetics and Nuclear Signaling

Background: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Human Splicing factor 3B subunit 3 protien

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Affinity purification

Dilution: IHC 1:100-1:400

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A