SGK1 Monoclonal Antibody | E-AB-22207

SGK1 Monoclonal Antibody | E-AB-22207 | Gentaur UK, US & Europe Distribution

Type: Monoclonal Antibody

Synonyms: OTTHUMP00000017247, Serine/threonine protein kinase SGK, Serine/threonine protein kinase Sgk1, Serine/threonine-protein kinase Sgk1, Serum and glucocorticoid regulated kinase, Serum/glucocorticoid regulated kinase 1, Serum/glucocorticoid regulated kinase, Serum/glucocorticoid-regulated kinase 1, SGK 1, SGK, SGK1, Sgk1 variant i3, SGK1

Application: IHC-p

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Reserch Areas: Cancer, Developmental Biology, Signal Transduction, Stem Cells

Background: Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic Peptide of SGK1

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification Method: Protein A purification

Dilution: IHC 1:100-200

Clone: Clone:4D12

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A